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J Mol Biol. 2003 Jun 20;329(5):853-7.

Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria.

Author information

1
Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5A, 02-106 Warsaw, Poland.

Abstract

The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

PMID:
12798676
DOI:
10.1016/s0022-2836(03)00528-x
[Indexed for MEDLINE]

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