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J Steroid Biochem Mol Biol. 2003 May;85(1):57-61.

The detection of 20S-hydroxycholesterol in extracts of rat brains and human placenta by a gas chromatograph/mass spectrometry technique.

Author information

1
Department of Obstetrics and Gynecology, The St. Luke's-Roosevelt Institute for Health Sciences, New York, NY 10019, USA.

Abstract

The presence of 20(S)-hydroxycholesterol in rat brains and human placenta has been established using the gas chromatography/mass spectrometry (GC/MS) select ion monitoring (SIM) technique. Identification was ensured by three criteria: the specific retention time when the compound emerges from the gas chromatogram and the two m/z ions (201 and 461amu) which are characteristic of its mass spectrum. The possible role of 20(S)-hydroxycholesterol in steroid hormone biosynthesis and in other biological processes is discussed.

PMID:
12798357
DOI:
10.1016/s0960-0760(03)00137-7
[Indexed for MEDLINE]

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