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Bioorg Med Chem Lett. 2003 Jul 7;13(13):2101-4.

Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates.

Author information

1
CombiChem Inc., 4570 Executive Drive, 92121, San Diego, CA, USA. ndelaet@kemia.com

Abstract

The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the D-diaminopropionic acid derivatives were shown to be single digit nanomolar PCP inhibitors.

PMID:
12798313
DOI:
10.1016/s0960-894x(03)00404-9
[Indexed for MEDLINE]

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