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J Am Chem Soc. 2003 Jun 18;125(24):7164-5.

A new strategy for improved nicotine vaccines using conformationally constrained haptens.

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1
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.

PMID:
12797775
DOI:
10.1021/ja034805t
[Indexed for MEDLINE]
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