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Arthritis Rheum. 2003 Jun;48(6):1701-7.

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis.

Author information

1
II Medical Clinic, University of Kiel, Kiel, Germany.

Abstract

OBJECTIVE:

To examine whether systemic administration of immunostimulatory and immunosuppressive oligodeoxynucleotides (ODNs) alter host susceptibility to inflammatory arthritis.

METHODS:

Normal BALB/c mice were treated systemically with CpG ODNs or suppressive ODNs, and then challenged intraarticularly with CpG DNA. The onset and magnitude of the resulting inflammatory response was monitored.

RESULTS:

Systemic delivery of CpG ODNs significantly increased susceptibility to local inflammation, whereas systemic treatment with suppressive ODNs reduced this susceptibility. CD11c+ cells played a key role in mediating host sensitivity to arthritis. These cells were the dominant source of tumor necrosis factor alpha production in CpG-stimulated animals and transferred resistance to arthritis from mice treated with suppressive ODNs.

CONCLUSION:

Systemic exposure to immunostimulatory and immunosuppressive DNA influences host susceptibility to local inflammatory challenge. Current findings raise the possibility that suppressive ODNs may be useful in the prevention/treatment of proinflammatory diseases.

PMID:
12794839
DOI:
10.1002/art.11035
[Indexed for MEDLINE]
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