Format

Send to

Choose Destination
Breast Cancer Res. 2003;5(3):164-73. Epub 2003 Apr 2.

The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer.

Author information

1
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. osth@usc.edu

Abstract

Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide.

PMID:
12793900
PMCID:
PMC165007
DOI:
10.1186/bcr593
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center