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Eur J Clin Nutr. 2003 Jun;57(6):793-800.

Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction.

Author information

1
Department of Clinical Chemistry, Central Hospital in Rogaland, POB 8100, 4068 Stavanger, Norway. heidi@madlalia.no

Abstract

OBJECTIVE:

To assess the oxidative burden of a highly concentrated compound of n-3 PUFAs as compared to corn oil by measuring thiobarbituric acid-malondialdehyde complex (TBA-MDA) by HPLC. We also studied the influence on TBA-MDA of statins combined with n-3 PUFAs or corn oil.

DESIGN:

A prospective, randomised, double-blind, controlled study.

SETTING:

One hospital centre in Stavanger, Norway.

SUBJECTS:

A total of 300 subjects with an acute myocardial infarction (MI).

INTERVENTIONS:

Gelatine capsules, containing 850-882 mg EPA and DHA as concentrated ethylesters, or 1 g of corn oil, were ingested in a dose of two capsules twice a day for at least 1 y. Alpha-tocopherol (4 mg) was added to all capsules to protect the PUFAs against oxidation.

RESULTS:

After 1 y TBA-MDA increased modestly in the n-3 PUFA group (n=125), as compared to the corn oil group (n=130), P=0.027. Multiple linear regression analyses of fatty acids in serum total phospholipids (n=56) on TBA-MDA measured after 12 months intervention, showed no dependency. Performing best subsets regression, serum phospholipid concentration of arachidonic acid (20:4 n-6 PUFA) was identified as a predictor of TBA-MDA at 12 months follow-up, P=0.004. We found no impact of statins on TBA-MDA.

CONCLUSION:

TBA-MDA increased modestly after long-term intervention with n-3 PUFAs compared to corn oil post-MI, suggesting biological changes induced by n-3 PUFAs, rather than simply reflecting their concentration differences. The peroxidative potential of n-3 PUFAs was not modified by statin treatment.

SPONSORSHIP:

: Pharmacia A/S and Pronova A/S, Norway.

PMID:
12792664
DOI:
10.1038/sj.ejcn.1601730
[Indexed for MEDLINE]
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