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Neuroepidemiology. 2003 Jul-Aug;22(4):249-54.

Reproductive factors have low impact on the risk of different primary brain tumours in offspring.

Author information

1
Department of Clinical Science, Obstetrics and Gynaecology, UmeƄ, Sweden. Ingrid.Mogren@obgyn.umu.se

Abstract

OBJECTIVES:

The aim of our study was to investigate whether reproductive factors influence the risk of primary brain tumours (PBT) in offspring.

METHODS:

Data on all deliveries in two Swedish counties from 1955 to 1990 were extracted from two birth registries. The follow-up period closed at the end of 1994, with subjects followed up to early middle age. Incidence rates of malignancy for 1958-1994 were obtained from the Swedish Cancer Registry. Standardised incidence ratios (SIR) and relative risks were calculated for astrocytomas, primitive neuroectodermal tumour, ependymoma and meningiomas in offspring.

RESULTS:

Few associations were detected. High birth weight indicated an increased risk for astrocytomas grade I and II for all primary brain tumours, and the risk was close to significance for astrocytomas grade I-II (SIR = 3.64; CI = 0.98-9.31). For children under 15 years of age the risk for astrocytomas grade I and II was further increased (SIR = 4.44; CI = 1.19-11.38).

CONCLUSIONS:

A consistent pattern of non-association indicated a low impact of intrauterine environment on the future development of primary brain tumours in offspring up to early middle age.

PMID:
12792146
DOI:
10.1159/000070567
[Indexed for MEDLINE]

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