Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2003 Jun 6;300(5625):1529-30.

Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions.

Author information

1
Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA.

Abstract

Wnts control the specification of cell fate, cell adhesion, migration, polarity, and proliferation. Their roles in development have been probed in fruit flies, nematodes, zebrafish, frogs, and mice. Some Wnts inhibit the degradation of beta-catenin, which can regulate transcription of specific genes. Other Wnts exert their influences in other ways, such as increasing intracellular concentrations of Ca2+ and decreasing intracellular concentrations of cyclic guanosine monophosphate (cGMP). Heterotrimeric guanine nucleotide-binding proteins (G proteins) and RGS proteins have been implicated in Wnt signaling. Wnt regulation of intracellular Ca2+ and cGMP levels requires the G protein transducin and a cGMP-specific phosphodiesterase, which are major elements in signaling of the visual pathway.

PMID:
12791979
DOI:
10.1126/science.1085259
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center