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Trends Cell Biol. 2003 Jun;13(6):295-300.

Signals for COPII-dependent export from the ER: what's the ticket out?

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Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.


Export of many secretory proteins from the endoplasmic reticulum (ER) relies on signal-mediated sorting into ER-derived transport vesicles. Recent work on the coat protein complex II (COPII) provides new insight into the mechanisms and signals that govern this selective export process. Conserved di-acidic and di-hydrophobic motifs found in specific transmembrane cargo proteins are required for their selection into COPII-coated vesicles. These signaling elements are cytoplasmically exposed and recognized by subunits of the COPII coat. Certain soluble cargo molecules depend on receptor-like proteins for efficient ER export, although signals that direct soluble cargo into ER-derived vesicles are less defined.

[Indexed for MEDLINE]

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