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J Gen Virol. 1992 Nov;73 ( Pt 11):2983-7.

Infection of macaque monkeys with a chimeric human and simian immunodeficiency virus.

Author information

1
Institute for Virus Research, Kyoto University, Japan.

Abstract

Two macaque monkeys were inoculated with a chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu and env genes of human immunodeficiency virus type 1. Infectious virus was recovered from one of the monkeys at 2 and 6 weeks post-infection. The hybrid nature of the isolated viruses was verified by Southern and Western blotting analyses. Both of the monkeys infected with the chimera elicited a humoral antibody response against the virus.

PMID:
1279105
DOI:
10.1099/0022-1317-73-11-2983
[Indexed for MEDLINE]

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