Regiospecific synthesis of 3-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine

Alan R Katritzky; Yong-Jiang Xu; Hongbin Tu

doi:10.1021/jo026797p

Regiospecific synthesis of 3-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine

J Org Chem. 2003 Jun 13;68(12):4935-7. doi: 10.1021/jo026797p.

Authors

Alan R Katritzky¹, Yong-Jiang Xu, Hongbin Tu

Affiliation

¹ Center for Heterocyclic Chemistry, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu

PMID: 12790603
DOI: 10.1021/jo026797p

Abstract

3-Substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine were obtained regiospecifically in yields of 35-92% in one pot by reaction of 2-aminopyridines or 2-(or 4-)aminopyrimidines, respectively, with 1,2-bis(benzotriazolyl)-1,2-(dialkylamino)ethanes.