Send to

Choose Destination
See comment in PubMed Commons below
IDrugs. 2003 Feb;6(2):129-37.

Morphinan derivatives--A review of the recent patent literature.

Author information

NiKem Research Srl, Via Zambeletti 25, 20021 - Baranzate di Bollate, Milan, Italy.

Erratum in

  • IDrugs. 2003 Mar;6(3):276.


Alkaloids extracted from the Papaverum somniferum are among the most powerfully acting and clinically used drugs for diseases of the central nervous system, in particular for pain. The basic ring system, common to these opiate alkaloids, is the morphinan skeleton, which in the last 50 years has been chemically manipulated to obtain compounds with improved potency and increased selectivity toward different populations of opioid receptors. Despite a huge amount of research, interest surrounding these compounds is still high. This review will discuss the patent applications published from January 2001 to June 2002, focusing on new chemical entities that could become drugs over the next few years, new chemical processes for the production of the morphinans currently used in therapy, novel formulations and combined compositions.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center