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J Ethnopharmacol. 2003 Jul;87(1):115-7.

Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.

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1
SIBR, Inc., 4112 20th Street West, Bradenton, FL 34205, USA.

Abstract

The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1% corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics (non-insulin-dependent diabetes mellitus, NIDDM). Subjects received a daily oral dose of Glucosol and blood glucose levels were measured. Glucosol at daily dosages of 32 and 48mg for 2 weeks showed a significant reduction in the blood glucose levels. Glucosol in a soft gel capsule formulation showed a 30% decrease in blood glucose levels compared to a 20% drop seen with dry-powder filled hard gelatin capsule formulation (P<0.001), suggesting that the soft gel formulation has a better bioavailability than a dry-powder formulation.

PMID:
12787964
[Indexed for MEDLINE]

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