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Dement Geriatr Cogn Disord. 2003;16(2):113-8.

Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke.

Author information

1
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK.

Abstract

AIM:

The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits.

METHOD:

Detailed neuropsychological assessments (attention and working memory) were undertaken in 50 stroke survivors >75 years of age [38 with ageing-associated cognitive decline (AACD)] and 15 age-matched controls. A 1.5-tesla General Electric MRI scanner was used. Standardized visual ratings were undertaken of white matter hyperintensities (WMH). Grey matter volumes were assessed using voxel-based morphometery.

RESULTS:

Associations were identified between processing speed and executive function and the severity of WMH in key areas. In addition, atrophy in the fronto-subcortical circuits was associated with AACD.

CONCLUSION:

Attentional and executive impairments are underpinned by WMH in fronto-striato-thalamo-frontal circuits. Frontal atrophy is identified as a novel substrate of cognitive decline in stroke patients.

PMID:
12784036
DOI:
10.1159/000070684
[Indexed for MEDLINE]

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