Format

Send to

Choose Destination
Trends Microbiol. 2003 May;11(5):220-3.

Life without dihydrofolate reductase FolA.

Author information

1
Institut de Génétique et Microbiologie CNRS UMR8621, Université de Paris-Sud, Orsay, France. hannu.myllykallio@igmors.u-psud.fr

Abstract

Reduced folate derivatives participate in numerous reactions of bacterial intermediary metabolism. Consequently, the well-characterized enzyme implicated in the formation of tetrahydrofolate--dihydrofolate reductase FolA--was considered to be essential for bacterial growth. However, comparative genomics has revealed several bacterial genome sequences that appear to lack the folA gene. Here, we provide in silico evidence indicating that folA-lacking bacteria use a recently discovered class of flavin-dependent thymidylate synthases for deoxythymidine-5'-monophosphate synthesis, and propose that many bacteria must contain uncharacterized sources for reduced folate molecules that are still waiting to be discovered.

PMID:
12781525
DOI:
10.1016/s0966-842x(03)00101-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center