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Bioorg Med Chem Lett. 2003 Jun 16;13(12):1977-80.

Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.

Author information

1
UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 5, Montpellier Cedex, France. balas@pharma.univ-montpl.fr

Abstract

Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.

PMID:
12781177
DOI:
10.1016/s0960-894x(03)00348-2
[Indexed for MEDLINE]

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