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Colorectal Dis. 2002 May;4(3):205-207.

Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol.

Author information

1
Discipline of Surgical Science Faculty of Medicine and Health Sciences The University of Newcastle.

Abstract

OBJECTIVE:

To observe the effect of Indole-3-carbinol (I3C), a naturally occurring component of cruciferous vegetables, on cell proliferation of a colon cancer cell line.

METHODS:

Cell proliferation was measured using three different methods; 3H-thymidine incorporation, cell count and colourimetric assay.

RESULTS:

Each method of measurement revealed that I3C significantly reduced cell proliferation at concentrations of > 0.1 mM.

CONCLUSION:

The present study demonstrates for the first time the capacity of indole-3-carbinol to inhibit cell proliferation of a colon cancer cell line.

PMID:
12780618

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