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Psychiatr Clin North Am. 2003 Jun;26(2):353-65.

Predictors of response in depression.

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  • 1Outpatient Specialty Programs, Department of Psychiatry and Behavioral Science, University of Miami School of Medicine, Suite 304A, 1400 North West 10th Avenue, Miami, FL 33136, USA.


Conflicting or sparse data on predictors of treatment response in depression have resulted in lack of clear guidelines in choosing antidepressant treatment. Critical to treatment outcome are accurate diagnosis and adequate treatment. Other data easy to obtain, such as age, gender, and marital status, have failed to be consistent predictors; more elaborate studies, such as receptor analysis or neuroimaging, are not yet accessible to most clinicians or economically feasible; however, they offer hope for the future, when more biologically based diagnostic distinctions may come to guide treatment choices.

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