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Nat Rev Cancer. 2003 Jun;3(6):444-51.

Contribution of stem cells and differentiated cells to epidermal tumours.

Author information

1
Cancer Research UK, London Research Institute, Keratinocyte Laboratory, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Abstract

The outer covering of the skin--the epidermis--is subject to sustained environmental assaults. As a result, many cells acquire potentially oncogenic mutations. Most cells are lost through differentiation, and only long-term epidermal residents, such as stem cells, accumulate the number of genetic hits that are necessary for tumour development. So, what genetic and environmental factors determine whether a mutant stem cell forms a tumour and what type of tumour will develop?

PMID:
12778134
DOI:
10.1038/nrc1096
[Indexed for MEDLINE]
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