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Nat Rev Mol Cell Biol. 2003 Jun;4(6):497-502.

The present view of the mechanism of protein folding.

Author information

1
Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, Washington 98195-7610, USA. daggett@u.washington.edu

Abstract

We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.

PMID:
12778129
DOI:
10.1038/nrm1126
[Indexed for MEDLINE]

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