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Mol Neurobiol. 2003 Apr;27(2):223-38.

Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea.

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Université de Montpellier I, Institute des Neurosciences de Montpellier, INSERM U583, 34090 Montpellier, France.


Mechanosensory hair cells of the vertebrate cochlea offer an excellent developmental system to study cell-fate specification, and to gain insight into the many human neurological deficits which result in a hearing loss, by affecting primarily the hair cells. Therefore, there is great interest in studying the molecular mechanisms that regulate their specification and differentiation. Recent studies, based mostly on loss-of-function experiments that target the role of Notch signaling and basic helix-loop-helix genes in inner-ear development have indicated that they can regulate mechanosensory hair cell-fate specification and their initial differentiation.

[Indexed for MEDLINE]

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