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Zhongguo Zhong Yao Za Zhi. 2001 Sep;26(9):617-20.

[Protection against paracetamol-induced hepatic damage using total flavonoids of Astragalus].

[Article in Chinese]

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Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Department of Biochemistry, PLA General Hospital, Beijing 100853.



To study the mechanism of the protection by total flavonoids of Astragalus protection against paracetamol-induced hepatic damage.


Analysing paracetamol and its metabolites in mice urine by HPLC and studying the mechanism of anti-damage induced by paracetamol using experiment module of pentobarbital-induced sleeping time.


Administration of large doses of paracetamol to C57BL/6J mice produced significant hepatic injury with marked elevation in serum ALT activity and severe hepatocellular necrosis. TFA showed a good protective capability against paracetamol-induced hepatic injury. TFA had no marked effect on paracetamol and its metabolites except for the mercapturate-conjugate. The concentration of mercapturate change decreased with increasing TFA dose. TFA had no effect on the pentobarbital metabolites (P > 0.05). However, paracetamol (400 prolonged the sleeping time (by 110 min relative to the controls, P < 0.001). The TFA (P < 0.005) caused significant reduction in paracetamol-prolonged pentobarbital-induced sleep.


The mechanism of TFA's protective effect against the paracetamol-induced damage may be related to the inhibition of some metabolism progress of paracetamol and the reduction of the toxicity metabolite such as mercapturate-conjugate.

[Indexed for MEDLINE]

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