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Zhongguo Zhong Yao Za Zhi. 2001 Jul;26(7):483-6.

[Studies on protective effect of total flavonoids of Astragalus on liver damage induced by paracetamol].

[Article in Chinese]

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Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China.



To study the protective effect of total flavonoids of Astragalus (TFA) on the liver against large doses of paracetamol in mice.


After oral administration of TFA or Vitamin C 1 h prior to giving large dose of paracetamol in mice, the changes of paracetamol-induced mortality rate, serum enzyme level and liver damage degree were observed.


Paracetamol produced 80% mortality, within 24 hours of the administration of a dose of 1000 to the mice. Pre-treatment of the animals with TFA (100 or Vitamin C (1,000 reduced the death rate to 20% and 0% respectively. There was also a significant rise in the serum enzyme level of alanine transaminase (P < 0.001) and the area of liver necrosis (P < 0.001), 24 h after paracetamol (400 treatment. With pre-treatment with either TFA or Vitamin C, there was an obvious dose-dependent decrease in ALT levels and the area of hepatocellular necrosis.


TFA has potential protecting effect against the paracetamol-induced hepatic damage.

[Indexed for MEDLINE]

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