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Zhongguo Zhong Yao Za Zhi. 2001 Nov;26(11):773-7.

[The protective effects of yi-xin-kang capsule on the structure and function of rat myocardial mitochondria].

[Article in Chinese]

Author information

1
Beijing Institute of Radiation Medicine, Beijing 100850, China.

Abstract

OBJECT:

To observe the injury induced by Isoproterenol (ISO) on the structure and function of rat myocardial mitochondria and the protective effects of Yi-Xin-Kang Capsule (H303).

METHOD:

After injection of ISO, rat myocardial mitochondria were isolated. The activities of phospholipidase A2(PLA2) and Ca(2+)-ATPase, the content of phospholipids (PL) and high-energy phosphates, membrane lipid fluidity (LFU) and respiration function were determined respectively.

RESULT:

ISO induced severe injury to myocardial mitochondria. The activity of PLA2 was significantly activated. The intensity of LFU, the activity of Ca(2+)-ATPase, respiration function of mitochondria and the contents of PL and high-energy phosphates of myocardium tissue were significantly decreased. Oral administration of H303 significantly decreased the activity of PLA2. The contents of PL and LFU, the activity of Ca(2+)-ATPase were significantly increased. The respiration function of mitochondria was protected by accelerating III state respiration rate, improving ADP/O ratio and recovering the depressed respiration control rate.

CONCLUSION:

H303 possessed protective effect on structural and functional injury of mitochondria induced by ISO.

PMID:
12776352
[Indexed for MEDLINE]

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