Format

Send to

Choose Destination
See comment in PubMed Commons below
Zhongguo Zhong Yao Za Zhi. 2001 Dec;26(12):853-6.

[The effect of kudingcha (Ilex latifolia Thunb.) on the contraction of isolated guinea-pig tracheal smooth muscle in vitro].

[Article in Chinese]

Author information

1
Department of Pharmacy, Sun Yat-Sen University, Guangzhou 510275, Guangdong, China.

Abstract

OBJECTIVE:

To study the effects of Kudingcha (Ilex latifolia Thunb., IL) on the isolated guinea pig tracheal smooth muscle in vitro.

METHOD:

By obtaining CaCl2 and Histamine accumulative dose-response curves, to observe the influences of IL on the contraction of tracheal strips induced by calcium and some asthmogenic mediators.

RESULT:

CaCl2 and histamine caused significant contraction of tracheal smooth muscle and pD2 was 3.55 and 5.34 respectively. After incubated with IL, the dose-response curves of CaCl2 and histamine were significantly shifted to the right, and the maximal contractile force was reduced. IL could also inhibit isolated tracheal strip contraction induced by acetylcholine 3 x 10(-6) mol.L-1 and histamine 3 x 10(-6) mol.L-1, and IC50 was 0.16 mg.ml-1 and 0.21 mg.ml-1.

CONCLUSION:

Kudingcha has significant dilated effects on tracheal smooth muscle.

PMID:
12776338
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center