Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2003 Jun;3(6):472-82.

Lysosomal cysteine proteases regulate antigen presentation.

Author information

1
Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA. khoney@u.washington.edu

Abstract

Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment. Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating antigen presentation by both MHC class II and CD1D molecules.

PMID:
12776207
DOI:
10.1038/nri1110
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center