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EMBO Rep. 2003 Jun;4(6):571-4.

IQGAP proteins are integral components of cytoskeletal regulation.

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1
Brigham and Women's Hospital, Thorn 530, 75 Francis Street, Boston, MA 02115, USA.

Abstract

IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca(2+)/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E-cadherin-mediated cell-cell adhesion and beta-catenin-mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.

PMID:
12776176
PMCID:
PMC1319206
DOI:
10.1038/sj.embor.embor867
[Indexed for MEDLINE]
Free PMC Article
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