Format

Send to

Choose Destination
See comment in PubMed Commons below
EMBO J. 2003 Jun 2;22(11):2546-51.

Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity.

Author information

1
University of Milano-Bicocca, Department of Biotechnology and Bioscience, Milan, Italy.

Abstract

Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes.

PMID:
12773371
PMCID:
PMC156758
DOI:
10.1093/emboj/cdg261
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center