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Biochem Soc Trans. 2003 Jun;31(Pt 3):716-8.

Immunoglobulin-binding domains: Protein L from Peptostreptococcus magnus.

Author information

1
Division of Biochemistry and Molecular Biology, Institute of Biomolecular Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK.

Abstract

Protein L is a multidomain cell-wall protein isolated from Peptostreptococcus magnus. It belongs to a group of proteins that contain repeated domains that are able to bind to Igs without stimulating an immune response, the most characterized of this group being Protein A ( Staphylococcus aureus ) and Protein G ( Streptococcus ). Both of these proteins bind predominantly to the interface of C(H)2-C(H)3 heavy chains, while Protein L binds exclusively to the V(L) domain of the kappa -chain. The function of these proteins in vivo is not clear but it is thought that they enable the bacteria to evade the host's immune system. Two binding sites for kappa -chain on a single Ig-binding domain from Protein L have recently been reported and we give evidence that one site has a 25-55-fold higher affinity for kappa -chain than the second site.

PMID:
12773190
DOI:
10.1042/
[Indexed for MEDLINE]

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