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Br J Cancer. 2003 Jun 2;88(11):1682-6.

Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

Author information

1
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. D.J.Gunnel@bristol.ac.uk

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

PMID:
12771980
PMCID:
PMC2377147
DOI:
10.1038/sj.bjc.6600946
[Indexed for MEDLINE]
Free PMC Article

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