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Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.

Ovarian follicle populations of the rat express TGF-beta signalling pathways.

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Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Victoria 3168, Australia.


The transforming growth factor-beta (TGF-beta) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which when activated mediate gene transcription. Some members of the superfamily, notably activin, TGF-beta, GDF-9 and the bone morphogenetic proteins have been shown to influence ovarian function. Despite these actions, TGF-beta superfamily signalling pathways and specifically those within follicle population subtypes, have been poorly characterised in the ovary. We have shown that the ovary contains type I and II receptors and Smads, which enable it to transduce signals in response to TGF-beta superfamily members. It remains to be established however, as to which follicle subtypes these pathways are active in.

[Indexed for MEDLINE]

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