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Neurosci Lett. 2003 Jun 12;343(3):216-8.

Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.

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Central Nervous System Department, Sanofi-Synthélabo Recherche, 371 rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France.


Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.

[Indexed for MEDLINE]

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