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J Neural Transm (Vienna). 2003 Jun;110(6):651-7.

Possible increased risk for Alzheimer's disease associated with neprilysin gene.

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1
Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona, Spain.

Abstract

Neprilysin has recently been reported to be the major physiological Abeta-degradating enzyme. In this study we describe a new biallelic polymorphism in the 3'UTR of the neprilysin gene in a representative population sample. The (*)159C/C genotype was found to be associated with an increased risk for Alzheimer's disease in an age-dependent manner. Adjusting for sex and APOE status, an odds ratio of 2.74 (p < 0.05) was observed among patients under 75 years old.

PMID:
12768360
DOI:
10.1007/s00702-002-0807-3
[Indexed for MEDLINE]
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