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Eur J Med Chem. 2003 May;38(5):513-8.

Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties.

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1
Dipartimento di Tossicologia, Università degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. tcocco@unica.it

Abstract

A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.

PMID:
12767601
[Indexed for MEDLINE]
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