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Bioessays. 2003 Jun;25(6):538-41.

Mitochondrial biogenesis: which part of "NO" do we understand?

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1
Montreal Neurological Institute and Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

Abstract

A recent paper by Nisoli et al. [1] provides the first evidence that elevated levels of nitric oxide (NO) stimulate mitochondrial biogenesis in a number of cell lines via a soluble guanylate-cyclase-dependent signaling pathway that activates PGC1alpha (peroxisome proliferator-activated receptor gamma coactivator-1alpha), a master regulator of mitochondrial content. These results raise intriguing possibilities for a role of NO in modulating mitochondrial content in response to physiological stimuli such as exercise or cold exposure. However, whether this signaling cascade represents a widespread mechanism by which mammalian tissues regulate mitochondrial content, and how it might integrate with other pathways that control PGC1alpha expression, remain unclear.

PMID:
12766943
DOI:
10.1002/bies.10298
[Indexed for MEDLINE]
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