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Clin Infect Dis. 2003 Jun 1;36(11):1488-91. Epub 2003 May 16.

Mucormycosis (zygomycosis) in a heart-kidney transplant recipient: recovery after posaconazole therapy.

Author information

1
Corporación para Investigaciones Biológicas, Medellín, Colombia.

Abstract

We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species postoperatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) therapy, but salvage treatment with the new azole antifungal posaconazole (200 mg orally 4 times daily) resulted in dramatic clinical improvement as early as 1 week after the initiation of therapy that continued through 23 weeks of treatment, with marked clinical, mycological, and radiological improvements and no adverse events.

PMID:
12766845
DOI:
10.1086/375075
[Indexed for MEDLINE]

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