Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Infect Dis. 2003 Jun 1;36(11):1369-73. Epub 2003 May 16.

Outbreak of joint and soft-tissue infections associated with injections from a multiple-dose medication vial.

Author information

1
Epidemiology Program Office, Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA; and Tennessee Department of Health, Nashville, TN, USA. david.kirschke@state.tn.us

Abstract

An outbreak of Staphylococcus aureus joint and soft-tissue infections occurred after therapeutic injections in an outpatient setting. A physician performed intra-articular or soft-tissue injections on 17 patients in August 2001, and 5 (29%) were subsequently hospitalized for infections at the site. S. aureus was isolated from 4 patients, and all 4 isolates were indistinguishable by pulsed-field gel electrophoresis. Of 10 patients injected with lidocaine and triamcinolone, 5 (50%) developed infections, compared with 0 of 7 patients injected with triamcinolone only (P=.04). A multiple-dose vial (MDV) of lidocaine was likely contaminated with S. aureus. A possible contributing factor was refrigeration after the use of MDVs of lidocaine; the manufacturer recommends storage at room temperature. An in vitro study of S. aureus in MDVs of lidocaine revealed prolonged survival at refrigerator temperatures. This outbreak highlights the importance of strict attention to aseptic procedures and carefully following manufacturers' instructions when using MDVs.

PMID:
12766830
DOI:
10.1086/375064
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center