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Vaccine. 2003 Jun 1;21 Suppl 2:S35-7.

Antigen dependent and independent mechanisms that sustain serum antibody levels.

Author information

1
Institute for Research in Biomedicine, Bellinzona, Switzerland.

Abstract

In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) polyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relative contribution of antigen induced short- and long-lived plasma cells versus polyclonal activation of all memory B cells. Antigenic boost sustains high levels of serum antibodies only for a few months, while polyclonal activation sustains low levels of protective antibodies for a human lifetime.

PMID:
12763680
DOI:
10.1016/s0264-410x(03)00198-1
[Indexed for MEDLINE]

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