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Brain Res Dev Brain Res. 2003 Jun 12;143(1):105-9.

Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing mouse brain.

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Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8509, Japan.


TROY is a recently identified member of the tumor necrosis factor (TNF) receptor superfamily. We investigated the expression pattern of TROY mRNA in the developing central nervous system by the in situ hybridization technique. TROY mRNA was strongly expressed in the ventricular zone and the subventricular zone, which contain neuronal and glial precursors during mouse embryogenesis. Its spatial and temporal expression patterns suggest that TROY plays some important roles in neurogenesis of embryonic stages.

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