Send to

Choose Destination
Funct Neurol. 2003 Jan-Mar;18(1):7-10.

TorsinA, microtubules and cell polarity.

Author information

Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Brescia, Italy.


Early-onset primary dystonia is an inherited disorder characterized by involuntary twisting, repetitive movements and abnormal postures. It has recently been demonstrated that the DYT1 gene is the most relevant gene associated with primary generalized dystonia. The DYT1 gene product is a 332-aminoacid long protein, termed TorsinA, whose function is still not clear. Based on the results obtained in other species, we proposed that TorsinA, similarly to OOC-5 in nematodes, directs and/or stabilizes the subcellular localization of specific kinases, which may in turn phosphorylate microtubule associated proteins, such as tau. In this way, TorsinA may contribute to maintaining the appropriate site-directed polarization and control neurite outgrowth.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center