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Trends Plant Sci. 2003 May;8(5):238-44.

Quorum quenching and proactive host defense.

Author information

1
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609. lianhui@imcb.a-star.edu.sg

Abstract

Both plants and humans have inducible defense mechanisms. This passive defense strategy leaves the host unprotected for a period of time until resistance is activated. Moreover, many bacterial pathogens have evolved cell-cell communication (quorum-sensing) mechanisms to mount population-density-dependent attacks to overwhelm the host's defense responses. Several chemicals and enzymes have been investigated for years for their potential to target the key components of bacterial quorum-sensing systems. These quorum-quenching reagents, which block bacterial cell-cell communications, can disintegrate a bacterial population-density-dependent attack. It has now been shown that a quorum-quenching mechanism can be engineered in plants and might be used as a strategy in controlling bacterial pathogens and to build up a proactive defense barrier.

PMID:
12758042
DOI:
10.1016/S1360-1385(03)00063-3
[Indexed for MEDLINE]

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