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Cancer Lett. 2003 May 15;194(2):183-8.

Telomeres in cancer and aging: lessons from the mouse.

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Department of Immunology and Oncology, National Centre of Biotechnology, E-28049, Madrid, Spain. <>


The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively.

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