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Neurosci Lett. 2003 May 22;342(3):139-42.

Interleukin-1beta increases spinal cord wind-up activity in normal but not in monoarthritic rats.

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  • 1Laboratory of Neurobiology, Department of Biological Sciences, Faculty of Chemistry and Biology, University of Santiago of Chile, Casilla 40 Correo 33, Santiago, Chile.


Cytokines produced by spinal cord glia after peripheral inflammation, infection or trauma have a relevant role in the maintenance of pain states. The effect of intrathecally administered interleukin-1beta (IL-1beta) on spinal cord nociceptive transmission was studied in normal and monoarthritic rats by assessing wind-up activity in a C-fiber-mediated reflex paradigm evoked by repetitive (1 Hz) electric stimulation. Low i.t. doses of IL-1beta (0.03, 0.12, 0.5 and 2.0 ng) dose-dependently enhanced wind-up activity in normal rats, while higher doses (8.0 ng) only produced a marginal unsignificant effect. IL-1beta administration to monoarthritic rats did not significantly change wind-up scores at any dose. Adaptive changes developed in the spinal cord during chronic pain may underlie the ineffectiveness of exogenous IL-1beta to up-regulate nociceptive transmission.

[PubMed - indexed for MEDLINE]
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