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J Pediatr. 2003 May;142(5):583-5.

Glutathione metabolism and antioxidant enzymes in children with Down syndrome.

Author information

1
Laboratory of Biochemistry, Molecular Medicine Unit, Children's Hospital and Research Institute Bambino Gesù, Rome, Italy.

Abstract

Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.

PMID:
12756395
DOI:
10.1067/mpd.2003.203
[Indexed for MEDLINE]

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