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Aliment Pharmacol Ther. 2003 May 15;17(10):1309-17.

The burden of illness of gastro-oesophageal reflux disease: impact on work productivity.

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1
Zynx Health, Inc., a subsidiary of Cerner Corporation, Los Angeles, CA 90212, USA. bdean@cerner.com

Abstract

BACKGROUND:

The impact of gastro-oesophageal reflux disease on work productivity has become increasingly important, as the symptoms of gastro-oesophageal reflux disease affect individuals in their productive years of life.

AIMS:

To assess the impact of gastro-oesophageal reflux disease on reduced work productivity and to identify the predictors of reduced productivity.

METHODS:

A sample of employed individuals reporting chronic heartburn was selected from US household mail survey respondents. Heartburn severity and frequency were recorded using a diary, and work productivity was assessed using the Work Productivity and Activity Impairment Questionnaire for Patients with Symptoms of Gastro-oesophageal Reflux Disease. Predictors of reduced productivity were evaluated.

RESULTS:

Over 30% of heartburn sufferers reported reduced productivity. Individuals with symptoms of gastro-oesophageal reflux disease (n = 1003) reported 6.0% reduced productivity attributable to symptoms. Over 48% of respondents with severe symptoms reported reduced productivity, compared with 40% and 12% of respondents with moderate and mild symptoms, respectively. Using logistic regression, severity, a younger age and nocturnal symptoms were associated with increased odds of reduced productivity. In those reporting nocturnal heartburn, medication use and sleep interference increased the odds of reduced productivity.

CONCLUSIONS:

Reduced work productivity is seen in a large proportion of subjects on prescription medication for gastro-oesophageal reflux disease. Symptom severity and nocturnal heartburn are significantly associated with reduced work productivity, particularly when nocturnal heartburn interferes with sleep.

[Indexed for MEDLINE]
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