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Int J Med Microbiol. 2003 Apr;293(1):87-93.

Host defences to Citrobacter rodentium.

Author information

1
Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK. t.t.macdonald@soton.ac.uk

Abstract

Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut.

PMID:
12755369
DOI:
10.1078/1438-4221-00247
[Indexed for MEDLINE]

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