Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Med. 2003 Jun;9(6):727-8. Epub 2003 May 18.

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

Author information

1
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.

Abstract

Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.

PMID:
12754504
DOI:
10.1038/nm880
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center