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J Bacteriol. 2003 Jun;185(11):3469-72.

Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli.

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1
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA.

Abstract

The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.

PMID:
12754247
PMCID:
PMC155394
[Indexed for MEDLINE]
Free PMC Article
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