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Kidney Int Suppl. 2003 Jun;(85):S111-4.

Higher impact of mineral metabolism on cardiovascular mortality in a European hemodialysis population.

Author information

1
Nephrology Service, Hospital Universitari Arnau de Vilanova and Department of Medicine, University of Lleida, Spain. mmarco@arnau.scs.es

Abstract

BACKGROUND:

Cardiovascular disease is the main cause of morbidity and mortality among hemodialysis patients. Chronic renal failure influences a number of factors that cause accelerated atherogenesis, with calcium, phosphorus, and PTH playing key roles. Several studies have demonstrated the influence of these factors on all-cause and cardiovascular mortality in the American hemodialysis population. In the present study we evaluated the variables that influence long-term cardiovascular mortality in a European hemodialysis population.

METHODS:

One hundred and forty-three hemodialysis patients were followed for six years. Several Cox models were used to study the influence of demographic and biochemical data, and comorbid conditions in cardiovascular survival, with a particular interest in mineral metabolism.

RESULTS:

There was an increased risk of cardiovascular death in patients with serum P>6.5 mg/dL (risk ratio [RR], 2.5), PTH>50 pmol/L (RR, 3.9), Ca x P>52 (RR, 2.8), BB or Bb genotype (RR, 3.8), and in diabetics.

CONCLUSION:

There is a stronger influence of mineral metabolism on cardiovascular death among European patients when compared to the American population.

PMID:
12753279
DOI:
10.1046/j.1523-1755.63.s85.26.x
[Indexed for MEDLINE]

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